Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
60 mg
67%
Green Tea Extract(Leaf) (up to 32 mg of naturally occurring caffeine)(min. 40% Catechins)
400 mg
†
Top Medical Research Studies
9
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
8
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Read More
Most Useful Reviews
9
Cysts resolved effectively
1 people found this helpful
Using this supplement alongside Indole resulted in the disappearance of cysts after three months. My overall cycle improved, and I felt great during treatment. I plan to order again for further benefits.
Read More
7.5
Supports hormonal stability
3 people found this helpful
This supplement was prescribed for my condition, and initially, I experienced a rise in blood pressure, but my body adjusted. Combined with other dietary supplements, it is highly effective for my autoimmune disorder.
Read More
6
Effective metabolism aid
3 people found this helpful
I bought this for my husband, as green tea is known to enhance metabolism and help with fat loss while retaining energy. It's a key ingredient in sports nutrition, aiding in weight management, which is crucial for his training.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8
- All Researches
9
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Read More
9
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
9
We examined the effects of ascorbyl palmitate (AP), a derivative of vitamin C, on the NLRP3 inflammasome, which plays a significant role in various autoimmune disorders. The research shows that AP effectively inhibits the activation of this inflammasome, suggesting it could be a powerful tool in managing inflammation-driven diseases.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Read More
9
We observed a fascinating case involving an 11-year-old boy suffering from symptoms of scurvy, a condition arising from severe vitamin C deficiency. This boy had multiple issues, including iron-deficiency anemia, symptoms resembling bone infections, and muscle inflammation, particularly in his legs. His selective diet, likely due to a mild developmental disorder, led to a significant deficiency in vitamin C.
After he was diagnosed, we administered intravenous and oral vitamin C, which remarkably eased his joint and muscle pain within just a week. Following four months of supplementation, he showed complete recovery with no lingering symptoms or abnormal lab findings.
Notably, we found high levels of certain pro-inflammatory markers, specifically interleukin-6, IL-17A, and IL-23, likely linked to an immune response involving T-helper 17 cells. This association presents an intriguing insight into the inflammatory processes that might be involved in scurvy and, potentially, in other autoimmune disorders.
Our observations hint that vitamin C might play a pivotal role in addressing inflammation linked to autoimmune conditions, paving the way for enhanced understanding and treatment options in the future.
After he was diagnosed, we administered intravenous and oral vitamin C, which remarkably eased his joint and muscle pain within just a week. Following four months of supplementation, he showed complete recovery with no lingering symptoms or abnormal lab findings.
Notably, we found high levels of certain pro-inflammatory markers, specifically interleukin-6, IL-17A, and IL-23, likely linked to an immune response involving T-helper 17 cells. This association presents an intriguing insight into the inflammatory processes that might be involved in scurvy and, potentially, in other autoimmune disorders.
Our observations hint that vitamin C might play a pivotal role in addressing inflammation linked to autoimmune conditions, paving the way for enhanced understanding and treatment options in the future.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cysts resolved effectively
1 people found this helpful
Using this supplement alongside Indole resulted in the disappearance of cysts after three months. My overall cycle improved, and I felt great during treatment. I plan to order again for further benefits.
Read More
7.5
Supports hormonal stability
3 people found this helpful
This supplement was prescribed for my condition, and initially, I experienced a rise in blood pressure, but my body adjusted. Combined with other dietary supplements, it is highly effective for my autoimmune disorder.
Read More
6
Effective metabolism aid
3 people found this helpful
I bought this for my husband, as green tea is known to enhance metabolism and help with fat loss while retaining energy. It's a key ingredient in sports nutrition, aiding in weight management, which is crucial for his training.
Read More
7.5
Improved hormone balance
1 people found this helpful
At my doctor’s suggestion, I started taking green tea to manage my hormone levels. After a month, I feel significantly better. The capsules are a convenient option as I struggle with drinking tea. I recommend this product, and it’s essential to consider individual experiences.
Read More
2
No detectable benefits
2 people found this helpful
I switched to this product as a substitute for my previous supplement, but unfortunately, I did not notice any positive changes. Instead, I experienced a burning sensation in my breasts which resolved after discontinuation. This might suggest it wasn't suitable for me.
Read More
Frequently Asked Questions
9
Cysts resolved effectively
1 people found this helpful
Using this supplement alongside Indole resulted in the disappearance of cysts after three months. My overall cycle improved, and I felt great during treatment. I plan to order again for further benefits.
7.5
Improved hormone balance
1 people found this helpful
At my doctor’s suggestion, I started taking green tea to manage my hormone levels. After a month, I feel significantly better. The capsules are a convenient option as I struggle with drinking tea. I recommend this product, and it’s essential to consider individual experiences.
7.5
Supports hormonal stability
3 people found this helpful
This supplement was prescribed for my condition, and initially, I experienced a rise in blood pressure, but my body adjusted. Combined with other dietary supplements, it is highly effective for my autoimmune disorder.
2
No detectable benefits
2 people found this helpful
I switched to this product as a substitute for my previous supplement, but unfortunately, I did not notice any positive changes. Instead, I experienced a burning sensation in my breasts which resolved after discontinuation. This might suggest it wasn't suitable for me.
6
Long-term commitment needed
I ordered green tea for my mother to aid in weight loss, and she mentioned that consistent use over four months is essential to see results.
9
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
9
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
7
We explored the potential of vitamin C as a treatment option for autoimmune disorders, particularly focusing on its benefits for conditions like Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). Our review of existing literature revealed a growing body of evidence suggesting that vitamin C supplementation can positively influence immune responses, which may help in managing these diseases.
The research indicates that vitamin C regulates the cytokine environment, which is essential for maintaining a balanced immune system. By modulating the immune response to autoantigens, vitamin C can potentially lessen the harmful effects of these autoimmune disorders. Furthermore, the antioxidant properties of vitamin C play a role in managing oxidative stress, a factor often associated with autoimmune conditions.
We also noted that vitamin C might enhance the effects of conventional therapies, such as chemotherapy and radiation treatment, when applied to hematological neoplasms. This suggests that vitamin C could serve as a beneficial adjuvant in standard treatment protocols, although its isolated effects on autoimmune diseases are still being understood.
The research indicates that vitamin C regulates the cytokine environment, which is essential for maintaining a balanced immune system. By modulating the immune response to autoantigens, vitamin C can potentially lessen the harmful effects of these autoimmune disorders. Furthermore, the antioxidant properties of vitamin C play a role in managing oxidative stress, a factor often associated with autoimmune conditions.
We also noted that vitamin C might enhance the effects of conventional therapies, such as chemotherapy and radiation treatment, when applied to hematological neoplasms. This suggests that vitamin C could serve as a beneficial adjuvant in standard treatment protocols, although its isolated effects on autoimmune diseases are still being understood.
8
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
5
We examined the potential influence of vitamin C on autoimmune disorders, particularly in relation to thyroid issues. The study highlighted how vitamin C, known for its antioxidant properties, could impact conditions like Graves' disease.
Interestingly, while some research suggested that vitamin C might be beneficial, particularly with intravenous administration, nosotros found a lack of solid evidence for oral vitamin C consumption in treating these autoimmune diseases.
This point is significant because autoimmune thyroid diseases can affect antioxidant levels in the body, and changes in vitamin C levels have been observed in some patients. However, it's important to state clearly that the therapeutic effects of vitamin C on these conditions remain largely unproven, leaving room for further exploration.
Overall, while there’s a glimmer of hope from certain studies, the overall consensus is that we need more research to determine how effective vitamin C really is for autoimmune thyroid disorders.
Interestingly, while some research suggested that vitamin C might be beneficial, particularly with intravenous administration, nosotros found a lack of solid evidence for oral vitamin C consumption in treating these autoimmune diseases.
This point is significant because autoimmune thyroid diseases can affect antioxidant levels in the body, and changes in vitamin C levels have been observed in some patients. However, it's important to state clearly that the therapeutic effects of vitamin C on these conditions remain largely unproven, leaving room for further exploration.
Overall, while there’s a glimmer of hope from certain studies, the overall consensus is that we need more research to determine how effective vitamin C really is for autoimmune thyroid disorders.
8
We explored the potential relationship between dietary antioxidant capacity, specifically vitamin C levels, and the severity of multiple sclerosis (MS), a prevalent autoimmune disorder that affects the central nervous system. Our study involved 220 MS patients who completed dietary questionnaires focused on their intake of various antioxidants and other relevant health data.
Dividing the patients into two groups based on their Expanded Disability Status Scale (EDSS) scores, we observed that certain vitamins, including A, D, E, and C, showed significant differences between patients with lower and higher EDSS scores. The findings suggested an interesting correlation, particularly that vitamin C, along with other vitamins, was linked to the overall severity of MS symptoms.
However, we acknowledged that while vitamin C levels appeared to be associated with illness severity, the study did not isolate vitamin C's effects from other dietary antioxidants, meaning we can't fully conclude its individual impact. Future clinical trials are suggested to delve deeper into the role of vitamin C and other antioxidants in treating MS, potentially shaping more effective treatment strategies.
Dividing the patients into two groups based on their Expanded Disability Status Scale (EDSS) scores, we observed that certain vitamins, including A, D, E, and C, showed significant differences between patients with lower and higher EDSS scores. The findings suggested an interesting correlation, particularly that vitamin C, along with other vitamins, was linked to the overall severity of MS symptoms.
However, we acknowledged that while vitamin C levels appeared to be associated with illness severity, the study did not isolate vitamin C's effects from other dietary antioxidants, meaning we can't fully conclude its individual impact. Future clinical trials are suggested to delve deeper into the role of vitamin C and other antioxidants in treating MS, potentially shaping more effective treatment strategies.
References
- Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, et al. Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis. Food Funct. 2025;16:673. 10.1039/d4fo03096f
- Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. 10.1017/S0007114524001715
- Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. 10.1186/s12964-024-01756-x
- Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, et al. Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int J Mol Sci. 2024;25. 10.3390/ijms25137284
- Ali A, Jori C, Kumar A, Vyawahare A, Kumar J, et al. A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis. Biomater Sci. 2024;12:3389. 10.1039/d4bm00243a
- Zhang Y, Zhen S, Xu H, Sun S, Wang Z, et al. Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. Biosci Trends. 2024;18:187. 10.5582/bst.2024.01037
- Zhang L, Li G, Lin B, He H, Zhou R, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome. Int Immunopharmacol. 2024;131:111915. 10.1016/j.intimp.2024.111915
- Santiworakul C, Saisorn W, Siripen N, Leelahavanichkul A, Rianthavorn P. Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency. Pediatr Nephrol. 2024;39:1135. 10.1007/s00467-023-06189-1
- Mungan S, Guzel I, Demirdogen BC. Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis. Braz J Med Biol Res. 2023;56:e12776. 10.1590/1414-431X2023e12776
- Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab. 2023;6:e432. 10.1002/edm2.432
- Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, et al. Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep. 2023;7:302. 10.1093/mrcr/rxac059
